DNA215 Apr 2014

What is cellular senescence?

column_full] The process of cellular senescence was first described in a seminal study by Hayflick and Moorhead (1961) in which they observed that normal human fibroblasts were able to enter a state of irreversible growth arrest after serial cultivation in vitro; meanwhile cancer cells did not enter this growth arrest state and proliferated indefinitely. Hayflick and Moorhead (1961) presciently hypothesized the existence of cellular factors, whose loss through consecutive cell divisions limited the proliferation of